Selected publications
2020
Buczak, K., Kirkpatrick, J. M., Truckenmueller, F., Santinha, D., Ferreira, L., Roessler, S., Singer, S., Beck, M.#, and Ori, A.# (2020). Spatially resolved analysis of FFPE tissue proteomes by quantitative mass spectrometry. Nat. Protoc.
Schüler, S. C.*, Gebert, N.*, and Ori, A. (2020). Stem cell aging: The upcoming era of proteins and metabolites. Mech. Ageing Dev., 190, 111288.
Gebert, N., Cheng, C. W., Kirkpatrick, J. M., Di Fraia, D., Yun, J., Schädel, P., Pace, S., Garside, G. B., Werz, O., Rudolph, K. L., Jasper, H., Yilmaz, Ö. H., and Ori, A. (2020). Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction. Cell Rep., 31.
Kelmer Sacramento, E., Kirkpatrick, J. M., Mazzetto, M., Baumgart, M., Bartolome, A., Di Sanzo, S., Caterino, C., Sanguanini, M., Papaevgeniou, N., Lefaki, M., Childs, D., Bagnoli, S., Terzibasi Tozzini, E., Di Fraia, D., Romanov, N., Sudmant, P. H., Huber, W., … Ori, A. (2020). Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation. Mol. Syst. Biol., 16, 1–22.
2019
Romanov N., Kuhn M., Aebersold R., Ori A., Beck M.# and Bork P.# (2019). Disentangling Genetic and Environmental Effects on the Proteotypes of Individuals. Cell, 177, 1308-1318.
Muntel J.*, Kirkpatrick J.*, Bruderer R., Huang T., Vitek O., Ori A.#, and Reiter L.# (2019) Comparison of Protein Quantification in a Complex Background by DIA and TMT Workflows with Fixed Instrument Time. J. Proteome Res., 18, 1340–1351.
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2018
Wyant G.*, Abu-Remaileh M.*, Frenkel E., Laqtom N., Dharamdasani V., Heinze I., Ori A.#, and Sabatini D.M.# (2018). NUFIP1 is a ribosome receptor for starvation-induced ribophagy. Science 360, 751-758.
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Parca L., Beck M., Bork P., and Ori A. (2018) Quantifying compartment‐associated variations of protein abundance in proteomics data. Mol. Syst. Biol. 14, e8131.
Heinze I.*, Bens M.*, Calzia E.*, Holtze S., Dakhovnik O., Sahm A., Kirkpatrick J.M., Szafranski K., Romanov N., Sama S.N., Holzer K., Singer S., Ermolaeva M., Platzer M.#, Hildebrandt T.#, and Ori A.# (2018). Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging. BMC Biol. 16, 1–18.
Buczak, K.*, Ori, A.*, Kirkpatrick, J.M., Holzer, K., Dauch, D., Roessler, S., Endris, V., Lasitschka, F., Parca, L., Schmidt, A., Zender, L., Schirmacher, P., Krijgsveld, J., Singer, S.#, and Beck, M.# (2018). Spatial Tissue Proteomics Quantifies Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma (HCC). Mol. Cell. Proteomics 17, 810–825.
Ermolaeva, M.#, Neri, F.#, Ori, A.#, and Rudolph, K.L.# (2018). Cellular and epigenetic drivers of stem cell ageing. Nat. Rev. Mol. Cell Biol. 19, 1–17.
2017
Mackmull, M.-T., Klaus, B, Heinze, I, Chokkalingam, M, Beyer, A, Russel, R. B., Ori, A.#, and Beck, M.# (2017). Landscape of nuclear transport receptor cargo specificity. Mol. Syst. Biol. 13, 962.
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Cellerino, A.#, and Ori, A.# (2017). What have we learned on aging from omics studies? Semin. Cell Dev. Biol. 70, 177–189.
2016
Ori, A.*, Iskar, M.*, Buczak, K., Kastritis, P., Parca, L., Andrés-Pons, A., Singer, S., Bork, P., and Beck, M. (2016). Spatiotemporal variation of mammalian protein complex stoichiometries. Genome Biol. 17, 47.
2015
Ori, A.*, Toyama, B.H.*, Harris, M.S., Bock, T., Iskar, M., Bork, P., Ingolia, N.T., Hetzer, M.W., and Beck, M. (2015). Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats. Cell Syst. 1, 224–237.
Mackmull, M.-T., Iskar, M., Parca, L., Singer, S., Bork, P., Ori, A.#, and Beck, M.# (2015). Histone Deacetylase Inhibitors (HDACi) Cause the Selective Depletion of Bromodomain Containing Proteins (BCPs). Mol. Cell. Proteomics 14, 1350–1360.
Poli, M.*, Ori, A.*, Child, T., Jaroudi, S., Spath, K., Beck, M., and Wells, D. (2015). Characterization and quantification of proteins secreted by single human embryos prior to implantation. EMBO Mol. Med. 7, 1465–1479.
2013
Ori, A., Banterle, N., Iskar, M., Andrés-Pons, A., Escher, C., Khanh Bui, H., Sparks, L., Solis-Mezarino, V., Rinner, O., Bork, P., Lemke, E. and Beck, M. (2013). Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines. Mol. Syst. Biol. 9, 648.
Proteomics of Aging lab 